Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme downstream of the cyclooxygenase enzymes, is upregulated by inflammatory stimuli and is involved in the inflammatory processes of cardiovascular diseases and cancer.Use of mPGES-1 inhibitors in microvascular disease:
Cardiovascular morbidity and mortality are common in chronic inflammatory diseases due to vascular inflammation and endothelial dysfunction.
Selective deletion of mPGES-1 activity leads to anti-inflammatory, vasodilatory and platelet inhibitory effects.
GS-248 –A First in Class opportunity with combined anti-inflammatory, vasodilatory and platelet inhibitory effects
Our research has revealed novel uses for mPGES-1 inhibitors in the treatment of microvascular inflammation and represents a unique opportunity for development of new medicines.